kilomentor

Kilomentor Blog Moves, Expands and Upgrades

kilomentor | 22 October, 2013 20:22


Since December 2006, the Kilomentor Blog has appeared under the auspices of  the blogging site, Chemical Blogs. Starting to-day, all the Kilomentor blogs including the archives can be found at the new site
www.kilomentor.com . Readers of the Kilomentor Blog have been most recently visiting more than 400 times every day; making more than 400,000 visits in the blog's  lifetime. This popularity has made this change possible. Thank you all.

Kilomentor will remain true to its original focus: to provide information, references, and ideas pertinent to chemical process development for anyone in the world with web access, at no charge to the recipients. Kilomentor aims to level the playing field so that anyone who knows synthetic organic chemistry can gain a working understanding of chemical process development; so the all these creative people start out with a more equal footing.

On this new site, you will see sales promotions. These advertisers research carefully where they place messages. It is very likely that their products and services  can be  useful to you, since the readers of Kilomentor have a lot in common. The advertisers fund the extra research now needed to keep this service going. When Kilomentor was first started, I had material collected over many years to work from and writing something useful took a much shorter time.

An effective way to express your appreciation for the Kilomentor is to click on these ads. Become informed about what these organizations have to make your life easier.

As always thanks for reading.

Clarke Slemon
the Kilomentor



  

  


Kilomentor Answers Questions

kilomentor | 03 August, 2013 19:35

This particular article now appears at http://www.kilomentor.com/2013/08/kilomentor-answers-questions

If Kilomentor is interested in a problem you introduce through a Kilomentor Comment and, so long as you are willing to have it examined in a public forum, my assessment in free. If I do not choose your problem to write about or if you want off-line, private, or proprietary advice, Kilomentor will provide consultation services delivered from Toronto Canada for $150 (Can)/ hour. Other costs incurred, such as travel, time on route to a different destination, on-line searches, photocopy charges etc. are extra. All private consultation is performed under a secrecy agreement. Contact can be begun at kilomentor@sympatico.ca My expertise can be further assessed from the LinkedIn entry for Clarke Slemon. The author of Kilomentor is retired and does not need to grab your money. Only the minutes actually committed to full-focused investigating of the problem and communicating with the client are billed. I I think I cannot help you I will not waste either my time or your money. I don’t do this for my living.

What you can learn during recrystallization of substantial amounts of intermediate

kilomentor | 20 July, 2013 00:00


The kilomentor blog is now being continued at www.kilomentor.com. All the blog articles have been copied to there. All new blogs concerning process development appear there. There is expanded keyword searching.
This particular article appears at http://www.kilomentor.com/2013/07/what-you-can-learn-during-recrystallization-of-substantial-amounts-of-intermediate

 

 

Isolation Using an Inert Solid Excipient as a Means for Assessing the Practical Purity Needed for a Processís Intermediates and/or to Prepare Impurities Samples for Developing Analytic Methods.

kilomentor | 27 June, 2013 15:55


The kilomentor blog has been transferred to www.kilomentor.com All new and old articles will appear there. Keywords have been added to make searching using the internal search engine more efficient. This particular article appears at http://www.kilomentor.com/2013/06/isolation-using-an-inert-solid-excipient-as-a-means-for-assessing-the-practical-purity-needed-for-a-processs-intermediates-andor-to-prepare-impurities-samples-for-developing-analytic-methods

 

 

Driving an Equilibrium by Removing Water by Reaction while Generating a Useful Strong Acid using an Interesting Solvent Choice

kilomentor | 27 June, 2013 02:00

The Kilomentor Blog is now being continued and updated at www.kilomentor.com  The old articles appear there and all new articles will only appear there. Keywords have been added to make searching using the internal search engine more efficient. This particular article appears at http://www.kilomentor.com/2013/06/driving-an-equilibrium-by-removing-water-by-reaction-while-generating-a-useful-strong-acid-using-an-interesting-solvent-choice

 

Continuous Chemical Flow Reactors that Scale so Well are not New

kilomentor | 11 May, 2013 23:32

  The Kilomentor Blog is now being continued and updated at www.kilomentor.com This particular article now appears at http://www.kilomentor.com/2013/05/continuous-chemical-flow-reactors-that-scale-so-well-are-not-new

 

 

Using the Bisulfite Adduct for Purification at Scale: Practical Purity and Purging of Impurities by the Process Steps

kilomentor | 26 March, 2013 02:01

This particular article can be found at http://www.kilomentor.com/2013/03/using-the-bisulfite-adduct-for-purification-at-scale-practical-purity-and-purging-of-impurities-by-the-process-steps in the new kilomentor blog

 

The Potential Use of Acetic Acid and Acetic Anhydride for performing Solvent Switches during Work-Ups

kilomentor | 05 March, 2013 11:47

The Kilomentor Blog is now being continued and updated at www.kilomentor.com This particular article appears at http://www.kilomentor.com/2013/03/the-potential-use-of-acetic-acid-and-acetic-anhydride-for-performing-solvent-switches-during-workups
 

A Question about Genotoxic Impurities

kilomentor | 03 March, 2013 05:15

 

The Kilomentor Blog is now being continued and updated at www.kilomentor.com This particular article appears at http://www.kilomentor.com/2013/03/a-question-about-genotoxic-impurities


Improving the Purity of Product from a Good-Enough Process

kilomentor | 18 January, 2013 03:03

  The Kilomentor Blog is now being continued and updated at www.kilomentor.com This particular article appears at http://www.kilomentor.com/2013/01/improving-the-purity-of-product-from-a-goodenough-process

The Problem of Oiling Out in Chemical Process Development

kilomentor | 10 January, 2013 02:03

The Kilomentor Blog is now being continued and updated at www.kilomentor.com This particular article appears at http://www.kilomentor.com/2013/01/the-problem-of-oiling-out-in-chemical-process-development



Selective Silyl Group Protection: A Possible Preparation for Scalable Extractive Separations using Acetonitrile and Hexane Phases

kilomentor | 28 November, 2012 02:21


The Kilomentor Blog is now being continued and updated at www.kilomentor.com This particular article appears at http://www.kilomentor.com/2012/11/selective-silyl-group-protection-a-possible-preparation-for-scalable-extractive-separations-using-acetonitrile-and-hexane-phases

Friedel Craft Work Up of Aluminum Chloride catalyzed Reaction At Scale

kilomentor | 14 November, 2012 01:53

The Kilomentor Blog is now being continued and updated at www.kilomentor.com. Old articles appear there and all new articles will appear only there. This particular article appears at http://www.kilomentor.com/2012/11/friedel-craft-work-up-of-aluminum-chloride-catalyzed-reaction-at-scale Keywords have been added to articles to make searching using the internal search engine more efficient and discriminating. Insert your search terms into the search engine on this site to see which of the more than 130 articles are pertinent.

Working Up Aluminum chloride catalyzed Friedel-Craft reactions At Scale

kilomentor | 14 November, 2012 01:49

The Kilomentor Blog is now being continued and updated at www.kilomentor.com

 

Larry Fertel asks a question about his Friedel Craft reaction at the

Organic Process Research & Development Networking Group on LinkedIn.
http://www.linkedin.com/groupItem?view=&gid=1902030&type=member&item=183287909&qid=a6702261-06ff-4897-b330-afc82910de9d&trk=group_most_popular-0-b-ttl&goback=%2Egmp_1902030

Larry wrote, “I am running a classical F-C reaction based on a process given to us from our customer: benzene derivative, benzoyl chloride (1.1 eq.), AlCl3 (1.1 eq), nitrobenzene solvent, 85 deg C, . i.e standard conditions. When I cool and quench into water and HCl or add water/HCl to the reaction, I am supposed to see 2 layers, then separate the aqueous and go forward with the isolation of the product in the organic layer, etc..

Instead, after the exotherm of quenching, I get massive amounts of solids, the stirrer jams, etc... a real mess. The solids are presumably Al salts

Removal of Hydroxyl Impurities from a Solid Product at Scale

kilomentor | 12 November, 2012 23:04

 The Kilomentor Blog is now being continued and updated at www.kilomentor.com This particular article appears at http://www.kilomentor.com/2012/11/removal-of-hydroxyl-impurities-from-a-solid-product-at-scale.

 

 

 

 

 

 

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