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kilomentor | 24 January, 2007 18:26
Creating rugged scaleable processes has always been important for process chemistry. Exploratory and early development small scale reactions are most frequently purified using chromatography, but chromatography is not readily scaled up and it is expensive. Larger scale requires more rationally selected purification methods. A goal of this presentation is to show how using sulfuric acid esters can efficiently and economically improve preparative scale organic synthesis.
(More)kilomentor | 24 January, 2007 17:58
I have proposed that a synthetic chemist can assess the relative merits of two or more routes of synthesis by looking at the proposed intermediates in the schemes and rating the likelihood that they can be separated cleanly and in good yield. Schemes that have a higher proportion of these preferred intermediates on balance are more promising. One intermediate that I propose that you can depend upon being readily isolated and efficiently purifiable is salts of organic acids and bases. Below I would like to may a variety of points which all apply to using salts of carboxylic acids as dependable intermediates.
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