kilomentor

1. This site will be presenting strategies for efficiently creating rugged chemical processes. By processes we mean a series of chemical steps and isolations which produce commercially interesting amounts of pure substances- my own experience of 40 years is with pharmaceutical actives. Here we get started by just considering some of the questions which a process chemist asks hinself/herself about a proposed transformation.

In organic chemistry, product isolation and purification is the most time consuming aspect of the art. It is the least intensively dealt with in the literature. Because preparative column chromatography is by far the most general and powerful of these methods, a thorough understanding of the available options is important. Over the years some highly refined and powerful methods have been designed for carrying out preparative scale separations; however, there has been no comprehensive description, tabulation or critical comparison of these second and third generation forms of preparative chromatography. This is the goal.

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• Pamoates or Embonates: crystalline Pharmaceutical Salts or Derivatives for Isolation and Purification
• Symmetrical Bis-N,N-(3-nitrophenyl)urea: A Super Co-crystal Former that might have applications in Product Purification.
• The Importance of the Molecular Weight of a Salt Former in choosing a Pharmaceutical Salt
• Reiterating the Objective of the Kilomentor Blog
• The process vision: an integrating strategy in pharmaceutical process development
• Phosphate Pharmaceutical Salts : Chemical Process Development & Organic Synthesis
• Green /Recyclable Solvents: Low Vapour pressure compositions for storage and recycling of solvents that are highly volatile or gaseous at room temperature
• Sulfate Pharmaceutical Salts
• Making the Hydrochloride Pharmaceutical Salt of Basic Drug Substances
• Kilomentor weighs in as “Pharmaceutical Manufacturing Goes Green”.
• Another Way to Separate Phenolics by Crystallizing of Co-crystals?
• The Complete Blog for the Preparation of Pharmaceutical Salts
• Inverted Filtration: A chemical synthesis laboratory technique particularly helpful at 5-10 litre scales.
• Recovering More Product by Crystallization in Organic Synthesis:Trituration with a Modified Water Phase as a Potential Chemical Process Development Method
• Kilomentor moves the discussion from Steam Distillation to other Co-distillations

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