kilomentor

Solvent Exchanges for Special High Boiling Solvents

kilomentor | 29 April, 2007 22:14

 

 

The Kilomentor Blog is now available in a more complete form at www.kilomentor.com . This particular article appears at http://www.kilomentor.com/2007/04/solvent-exchanges-for-special-high-boiling-solvents

 

 

 

 

 

 

 

 


Chemical terms boiling | solvent

Comments

Re: Solvent Exchanges for Special High Boiling Solvents

Freelance | 02/05/2007, 18:58

A very insightful article!

Re: Solvent Exchanges for Special High Boiling Solvents

cristy | 10/12/2007, 11:40

Very good!!! Keep working.

Re: Solvent Exchanges for Special High Boiling Solvents

Marto | 23/05/2008, 10:04

Dear KM,
Many thanks for your very insightful articles, it really helpful for me to
I would be really grateful if you could suggest me for removing cyclohexylmethanol from my reaction (BP : 180-181 oC) and its very viscous. I am really struggling to remove from the reaction mixture. I dont have any idea about lower boiling azeotrope with any solvents. i would be really grateful if you could suggest me some techniques. cheers Marto

Re: Solvent Exchanges for Special High Boiling Solvents

kilomentor | 23/05/2008, 12:24

In response to Marto 23 May 2008, separating a residual solvent from a mixture depends very much upon the properties of the material(s) you are separating from. Obviosly whatever that is it is not low boiling itself or the answer would be obvious. Steam distillation, steam distillation using live steam under vacuum might work. Dissolution in hexane and treatment with a large excess of anhydrous calcium chloride and a little catalytic amount of ethanol could make the insoluble complex between cyclohexylmethanol and calcium chloride. this is only possible if the desired product is not an alcohol itself.

Thanks for the question Marto.

Re: Solvent Exchanges for Special High Boiling Solvents

sivamangalesh | 23/05/2008, 17:51

Dear KM,

Many thanks for your help. I really appreciate for your prompt reply to my query

Remove DMF

Amelia | 02/06/2009, 08:53

Hi, I would like to know what is a good method to remove DMF from my compound. My compound is very polar (with acid and 2 phenol groups)and might not be very soluble in ether. As the compound is a sticky solid, I suspect a tiny amount of DMF is trapped in the solid as I tried freeze-dry vacuum and passing through silica gel column. Do you have a good idea? Thanks.

Sulfolane WorkUp

kilomentor | 25/11/2012, 14:34

Kilomentor would like to add a useful fact for working up reactions in the dipolar aprotic solvent sulfolane. This solvent is immiscible with tert-butyl methyl ether (TBME). Thus so long as the product is soluble in TBME it can be extracted with several portions from sulfolane and washed with a little water.

Add comment

authimage

 
Powered by LT - Design by BalearWeb