kilomentor

Improving the Purity of Product from a Good-Enough Process

kilomentor | 18 January, 2013 03:03

  The Kilomentor Blog is now being continued and updated at www.kilomentor.com This particular article appears at http://www.kilomentor.com/2013/01/improving-the-purity-of-product-from-a-goodenough-process

Comments

Re: Improving the Purity of Product from a Good-Enough Process

Christian | 21/02/2013, 04:32

"unidentified impurity can remain persistently and invariantly" that reminds me of how Pedersen discovered the crown ethers. For me as a scientist, the only acceptable solution would be isolation, purification and identification of this impurity.

Isolation diffculties

marto | 14/03/2013, 07:20

Dear Kilomentor,

I am trying to isolate CF3COAr (80% w/w assay) derivative compound from the ArBr (10% w/w and Piperidine COCF3 derivative (10% w/w) mixture . CF3COAr derivative is low melting solid (mp ~ 52 °C) and I dont have the distillation data of the same. I just would like to know whether bisulfite adduct isolation can be attempted on 25 kg scale or which method you would suggest. Small scale preparation involves isolation by precipitation (~ 50 % receovery) in cylcohexane at lower temp (- 20 °C).
Please suggest me if you have any experince

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