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Reactions on Immobilized Enzymes can Telescope Process Steps, Eliminate Isolations and Reduce Costs at All Stages of Pharmaceutical Development

kilomentor | 17 July, 2012 21:45


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Re: Reactions on Immobilized Enzymes can Telescope Process Steps, Eliminate Isolations and Reduce Costs at All Stages of Pharmaceutical Development

steven alley | 19/07/2012, 15:36

A question on solvates. We are having problems with a crystallisation process. Some batches filter and dry nicely. Others filter nicely but form slurries in the drier (20L rotary evaporator). The batches which slurry have lower yields (by 3-5%) and form lumps which require further processing to remove.

Crystallisation temperature, cooling profile and anti-solvent addition all seem reproducible. Solvent is water. Antisolvent is IPA.

We suspect an IPA solvate is forming in the problem batches. Any suggestions on how we might approach this problem would be gratefully recieved.

newprocesschemist

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