Separation of Diethyl Malonate and Monosubstituted Diethyl Malonate: Another Phase Switching Hdrolysis

kilomentor | 29 April, 2012 20:04


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Competitive hydrolysis

Slawomir | 30/04/2012, 07:06

That "shaking for 1 minute" would be hard to scale-up in batch mode. However, it seems to fit a continuous process just fine.

Some time ago when I made malonates for a living it was easier to over-alkylate and separate the mono product by distillation (the di-alkyl malonate was left in the pot).

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