kilomentor

How thinking about Separating Acetic acid and Acetic Anhydride can sharpen our Chemical Process Development Skills

kilomentor | 16 December, 2011 10:50

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Chemical terms acetic acid | acid

Comments

Re: How thinking about Separating Acetic acid and Acetic Anhydride can sharpen our Chemical Process Development Skills

Nick K | 22/12/2011, 10:06

I'm very late to the party, but I'll make a suggestion none the less: how about adding phthalic anhydride to dehydrate the acetic acid? Distillation would remove the acetic anhydride, making the reaction irreversible. Phthalic anhydride is cheap and less unpleasant than the other other dehydrating agents.

Re: How thinking about Separating Acetic acid and Acetic Anhydride can sharpen our Chemical Process Development Skills

Patrick Sweetman | 23/12/2011, 23:22

Reverse osmosis, if a suitable membrane is on the market.

Re: How thinking about Separating Acetic acid and Acetic Anhydride can sharpen our Chemical Process Development Skills

Tom | 11/01/2012, 08:33

If you added the acetic acid slowly to a large excess of sodium carbonate shouldn't you keep mixture basic and avoid producing any water? Or simply use sodium phosphate; perhaps I'm missing some obvious problem with this.

Re: How thinking about Separating Acetic acid and Acetic Anhydride can sharpen our Chemical Process Development Skills

Marto | 22/02/2012, 09:47

Dear Kilomentor,

I need to decide on a synthetic proposal. I am trying to prepare acyl derivative of an amino alcohol and I am planning to use acetic acid (1.5 equiv) and metal oxide (0.3 equiv) for this. I am not sure about the scalability of this. Aim is to develop a method for 1MT scale.

This reaction is neat reaction and work up involves filtration, followed by extraction using ethyl acetate and bicarbonate wash.

My only worry is that the product N-acylated amino alchol has water miscibility.

Distillation could be an option and BP of the product is 190 oC and the bp of the SM and acetic acid are well below that.

It would be really helpful if you have any suggestions for the scale up and merits/demerits of this

Cheers

Marto

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