The Kilomentor Approach-More Easily Isolated Intermediates-Fewer Technically Demanding Physical Separations.

kilomentor | 01 February, 2011 17:19

  The Kilomentor Blog is now being continued and updated at This particular article can be found at




Explosive intermediates

Curryworks | 04/02/2011, 18:09

With the advent of the azide alkyne cycloaddition reaction it seems the more academics play with this chemistry the more scared process chemist become. Several recent OPRD papers have featured possible alternate mechanisms to produce triazole functionality from non-azide sources. Would a process chemist ever produce a small molecule on scale or better stated is there a minimum number of carbons acceptable? On the other hand HN3 is used in DEAD reactions. Feelings?

Separation problem

marto | 22/11/2011, 13:23

I am having problem in the isolation of mixture containg biphenyl benzylacetate compound along with diarylated benzylacetate copound. I have been carrying out this reaction on 100 g- 200 g scale, the ration of biphenyl and diaryl compound is 10:1, isolation by recrsytallization was unsuccessful. Both have similar retention factor in TLC. suggest me any purification method for the isolation of these two compounds

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