kilomentor

The Use of the Diisopropyl ether (DIPE) Water Azeotrope as a possible means to dry high boiling dipolar aprotic solvents

kilomentor | 28 December, 2009 19:17

The Kilomentor Blog is now being continued and updated at www.kilomentor.com this particular article appears at http://www.kilomentor.com/2009/12/the-use-of-the-diisopropyl-ether-dipe-water-azeotrope-as-a-possible-means-to-dry-high-boiling-dipolar-aprotic-solvents


Chemical terms boiling | diisopropyl ether | water

Comments

Re: The Use of the Diisopropyl ether (DIPE) Water Azeotrope as a possible means to dry high boiling dipolar aprotic solvents

milkshake | 13/01/2010, 14:17

iPr2O is terrible as a process solvent because of very facile formation of peroxides (much more so than with Et2O) and these peroxides actually precipitate out and accumulate on the bottom of the barrel. Process people use tBuOMe instead.

Also Dean-Starking dipolar aprotic solvents would not work because they have a huge exotherm of mixing with water.

Whats wrong with using activated molecular sieves or with doing vacuum distillation from calcium hydride?

Re: The Use of the Diisopropyl ether (DIPE) Water Azeotrope as a possible means to dry high boiling dipolar aprotic solvents

NS 29 | 08/03/2010, 04:55

Molecular sieves sure work for the occasional liter of DMF or so. Molecular sieves are very painful to use on scale (abraison, bad filterability, the sieves tend to form very tightly packed filter cakes). Diisopropylether can be used on scale, exclusion of oxygen ist usually easier on scale than in the laboratory.

Re: The Use of the Diisopropyl ether (DIPE) Water Azeotrope as a possible means to dry high boiling dipolar aprotic solvents

tannas | 06/05/2010, 03:35

Other solvents that boil above 100 C that can potentially be separated from water and dried are: nitromethane, acetic acid, dioxane, ethylene diamine, sulfolane and isoamyl alcohol. good artical.
http://chemku.com

 
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