kilomentor

Separating Sulphur-containing from Sulphur-free Compounds both in the Lab and At Scale

kilomentor | 06 November, 2012 14:18

The Kilomentor Blog is now being continued and updated at www.kilomentor.com This particular blog appears at http://www.kilomentor.com/2012/11/separating-sulphurcontaining-from-sulphurfree-compounds-both-in-the-lab-and-at-scale




 

The Relationship between the Risk of Catastrophic Failure and the Size of the Scale Up Steps in Chemical Process Development

kilomentor | 16 October, 2012 10:51

 The Kilomentor Blog is now being continued and updated at www.kilomentor.com This particular article appears at http://www.kilomentor.com/2012/10/the-relationship-between-the-risk-of-catastrophic-failure-and-the-size-of-the-scale-up-steps-in-chemical-process-development

 


The Advantages of Transfer Hydrogenation for Chemical Process Scale Up

kilomentor | 29 September, 2012 17:53

The Kilomentor Blog is now being continued and updated at www.kilomentor.com This particular article appears at http://www.kilomentor.com/2012/09/the-advantages-of-transfer-hydrogenation-for-chemical-process-scale-up

 



Reactions on Immobilized Enzymes can Telescope Process Steps, Eliminate Isolations and Reduce Costs at All Stages of Pharmaceutical Development

kilomentor | 17 July, 2012 14:45


 The Kilomentor Blog is now being continued and updated at www.kilomentor.com
this particular article appears at http://www.kilomentor.com/2012/07/reactions-on-immobilized-enzymes-can-telescope-process-steps-eliminate-isolations-and-reduce-costs-at-all-stages-of-pharmaceutical-development

 

 

Current Process Chemistry: Improved Isolation from Enzyme in Enzyme Catalyzed Organic Process Steps

kilomentor | 10 July, 2012 11:50


The Kilomentor Blog is now being continued and updated at www.kilomentor.com

This particular article appears at http://www.kilomentor.com/2012/07/current-process-chemistry-improved-isolation-from-enzyme-in-enzyme-catalyzed-organic-process-steps



 

Current Process Chemistry Conference emphasizes Fit-for-Purpose Scaleup

kilomentor | 25 June, 2012 13:51

The Kilomentor Blog is now being continued and updated at www.kilomentor.com This particular article appears at http://www.kilomentor.com/2012/06/current-process-chemistry-conference-emphasizes-fitforpurpose-scaleup

 



Separation of Diethyl Malonate and Monosubstituted Diethyl Malonate: Another Phase Switching Hdrolysis

kilomentor | 29 April, 2012 20:04

 

  The Kilomentor Blog is now being continued and updated at www.kilomentor.com

This particular article appears at http://www.kilomentor.com/2012/04/separation-of-diethyl-malonate-and-monosubstituted-diethyl-malonate-another-phase-switching-hdrolysis

 

About Extracurricular Training

kilomentor | 16 April, 2012 07:40

The Kilomentor Blog is now being continued and updated at www.kilomentor.com This particular article appears at http://www.kilomentor.com/2012/04/about-extracurricular-training-can-kilomentor-get-you-a-job

 

A Large Rigid Acid for Making Crystalline Salts : 4’’-n-pentoxy-[1,1’:4,1’’]-terphenyl-4-carboxylic acid

kilomentor | 31 March, 2012 14:41

The Kilomentor Blog is now being continued and updated at www.kilomentor.com

 

 

Lasalocid and (-)-DAG: Practical Recyclable Chiral Acid Resolving Agents for Making Diastereomeric Salts.

kilomentor | 22 March, 2012 14:46


The Kilomentor Blog is now being continued and updated at www.kilomentor.com

 

When performing a chiral resolution at scale it is important  whether the resolving agent can be re-isolated, crystallized to a consistent purity  and thus practically  reused. When the resolving agent is a carboxylic acid, this is simpler when the the carboxylate salt of an alkali or alkaline earth metal is soluble in water while the free acid precipitates from water. Two common chiral acids have this characteristic: lasalocid and (-)DAG.


Lasalocid

Lasalocid sodium is a veterinary pharmaceutical available in large quantities. It is a chiral carboxylic acid that can be used to form diastereomeric salts with racemic amines. Based on tested examples it is predicted to work most dependably for primary amines that have their chiral centre at the alpha or beta position as well as tertiary amines with a proximate chiral centre with respect to the nitrogen atom. The ligand is capable of multipoint binding with the amine as it forms hydrogen bonds to many different oxygens. The ligand contains many different chiral centres. The molecule is made by fermentation.

The acid is relatively inexpensive. It was covered by US 4,129,580 which expired in 1998.

 

(-)-2,3;4,6-di-O-isopropylidene-2-keto-L-gulonic acid hydrate also called (-)-DAG

(-)-DAG is also a water insoluble chiral organic acid that can be used to resolve chiral asymmetric amines.

It is a relatively inexpensive compound that is used  an intermediate in the synthesis of Vitamin C.  It was first prepared by Reichstein et al. Helv. 17, 311 (1934). Its use for resolution was taught in the expired US patent 3,682,925 (1972).

More Discussion of Exhaustive Digestion in Chemical Process Development

kilomentor | 07 March, 2012 11:24

The Kilomentor Blog is now being continued and updated at www.kilomentor.com The present article appears at http://www.kilomentor.com/2012/03/more-discussion-of-exhaustive-digestion-in-chemical-process-development

 

Allophanates- Potentially Useful Reversible Highly Crystalline Solid Derivatives of Alcohols

kilomentor | 28 January, 2012 15:44

The Kilomentor Blog is now being continued and updated at www.kilomentor.com This particular article is available at http://www.kilomentor.com/2012/01/allophanates-potentially-useful-reversible-highly-crystalline-solid-derivatives-of--alcohols 

 

 

The Chemical Manufacturing Process Route Selection: The Inclusion of Phase Switching and its Relationship to Validation

kilomentor | 20 January, 2012 11:31

The Kilomentor Blog is now being continued and updated at www.kilomentor.com This particular article is available at http://www.kilomentor.com/2012/01/the-chemical-manufacturing-process-route-selection-the-inclusion-of-phase-switching-and-its-relationship-to-validation . Other pertinent articles relating to the subject can be located by putting your search terms into the search engine on this site.

A Question from the LinkedIn Organic Process Research & Development Group that Fosters Practicing Creativity

kilomentor | 14 January, 2012 15:24

The Kilomentor Blog is now being continued and updated at www.kilomentor.com This particular article is available at http://www.kilomentor.com/2012/01/a-question-from-the-linkedin-organic-process-research-and-development-group-that-fosters-practicing-creativity  Other pertinent articles relating to the subject can be located by putting your search terms into the search engine on this site.

 



 

 

The Strategy of using Split Runs in Chemical Process Development

kilomentor | 23 December, 2011 15:25

 The Kilomentor Blog is now being continued and updated at www.kilomentor.com This particular article is available at http://www.kilomentor.com/2011/12/the-strategy-of-using-split-runs-in-chemical-process-development   Other pertinent articles relating to the subject can be located by putting your search terms into the search engine on this site.



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