kilomentor | 22 October, 2013 13:22
Since December 2006, the Kilomentor Blog has appeared under the auspices of the blogging site, Chemical Blogs. Starting to-day, all the Kilomentor blogs including the archives can be found at the new site www.kilomentor.com . Readers of the Kilomentor Blog have been most recently visiting more than 400 times every day; making more than 400,000 visits in the blog's lifetime. This popularity has made this change possible. Thank you all.
Kilomentor will remain true to its original focus: to provide information, references, and ideas pertinent to chemical process development for anyone in the world with web access, at no charge to the recipients. Kilomentor aims to level the playing field so that anyone who knows synthetic organic chemistry can gain a working understanding of chemical process development; so the all these creative people start out with a more equal footing.
On this new site, you will see sales promotions. These advertisers research carefully where they place messages. It is very likely that their products and services can be useful to you, since the readers of Kilomentor have a lot in common. The advertisers fund the extra research now needed to keep this service going. When Kilomentor was first started, I had material collected over many years to work from and writing something useful took a much shorter time.
An effective way to express your appreciation for the Kilomentor is to click on these ads. Become informed about what these organizations have to make your life easier.
As always thanks for reading.
kilomentor | 03 August, 2013 12:35
This particular article now appears at http://www.kilomentor.com/2013/08/kilomentor-answers-questions
If Kilomentor is interested in a problem you introduce through a Kilomentor
Comment and, so long as you are willing to have it examined in a public forum,
my assessment in free. If I do not choose your problem to write about or if you
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can be further assessed from the LinkedIn entry for Clarke Slemon. The author
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my time or your money. I don’t do this for my living.
kilomentor | 19 July, 2013 17:00
The kilomentor blog is now being continued at www.kilomentor.com. All the blog articles have been copied to there. All new blogs concerning process development appear there. There is expanded keyword searching. This particular article appears at http://www.kilomentor.com/2013/07/what-you-can-learn-during-recrystallization-of-substantial-amounts-of-intermediate
kilomentor | 27 June, 2013 08:55
The kilomentor blog has been transferred to www.kilomentor.com All new and old articles will appear there. Keywords have been added to make searching using the internal search engine more efficient. This particular article appears at http://www.kilomentor.com/2013/06/isolation-using-an-inert-solid-excipient-as-a-means-for-assessing-the-practical-purity-needed-for-a-processs-intermediates-andor-to-prepare-impurities-samples-for-developing-analytic-methods
kilomentor | 26 June, 2013 19:00
Kilomentor Blog is now being continued and updated at www.kilomentor.com The old articles appear there and all new articles will only appear there. Keywords have been added to make searching using the internal search engine more efficient. This particular article appears at http://www.kilomentor.com/2013/06/driving-an-equilibrium-by-removing-water-by-reaction-while-generating-a-useful-strong-acid-using-an-interesting-solvent-choice
kilomentor | 11 May, 2013 16:32
The Kilomentor Blog is now being continued and updated at www.kilomentor.com This particular article now appears at http://www.kilomentor.com/2013/05/continuous-chemical-flow-reactors-that-scale-so-well-are-not-new
kilomentor | 25 March, 2013 19:01
This particular article can be found at http://www.kilomentor.com/2013/03/using-the-bisulfite-adduct-for-purification-at-scale-practical-purity-and-purging-of-impurities-by-the-process-steps in the new kilomentor blog
kilomentor | 05 March, 2013 03:47
Kilomentor Blog is now being continued and updated at www.kilomentor.com This particular article appears at http://www.kilomentor.com/2013/03/the-potential-use-of-acetic-acid-and-acetic-anhydride-for-performing-solvent-switches-during-workups
kilomentor | 02 March, 2013 21:15
The Kilomentor Blog is now being continued and updated at www.kilomentor.com This particular article appears at http://www.kilomentor.com/2013/03/a-question-about-genotoxic-impurities
kilomentor | 17 January, 2013 19:03
The Kilomentor Blog is now being continued and updated at www.kilomentor.com This particular article appears at http://www.kilomentor.com/2013/01/improving-the-purity-of-product-from-a-goodenough-process
kilomentor | 09 January, 2013 18:03
kilomentor | 27 November, 2012 18:21
The Kilomentor Blog is now being continued and updated at www.kilomentor.com This particular article appears at http://www.kilomentor.com/2012/11/selective-silyl-group-protection-a-possible-preparation-for-scalable-extractive-separations-using-acetonitrile-and-hexane-phases
kilomentor | 13 November, 2012 17:53
The Kilomentor Blog is now being continued and updated at www.kilomentor.com. Old articles appear there and all new articles will appear only there. This particular article appears at http://www.kilomentor.com/2012/11/friedel-craft-work-up-of-aluminum-chloride-catalyzed-reaction-at-scale Keywords have been added to articles to make searching using the internal search engine more efficient and discriminating. Insert your search terms into the search engine on this site to see which of the more than 130 articles are pertinent.
kilomentor | 13 November, 2012 17:49
The Kilomentor Blog is now being continued and updated at www.kilomentor.com
Larry Fertel asks a question about his Friedel Craft reaction at the
Process Research & Development Networking Group on LinkedIn.
Larry wrote, “I
am running a classical F-C reaction based on a process given to us from our
customer: benzene derivative, benzoyl chloride (1.1 eq.), AlCl3 (1.1 eq),
nitrobenzene solvent, 85 deg C, . i.e standard conditions. When I cool and
quench into water and HCl or add water/HCl to the reaction, I am supposed to
see 2 layers, then separate the aqueous and go forward with the isolation of
the product in the organic layer, etc..
Instead, after the exotherm of quenching, I get massive amounts of solids, the stirrer jams, etc... a real mess. The solids are presumably Al salts
kilomentor | 12 November, 2012 15:04
The Kilomentor Blog is now being continued and updated at www.kilomentor.com This particular article appears at http://www.kilomentor.com/2012/11/removal-of-hydroxyl-impurities-from-a-solid-product-at-scale.